Scramblase 1 Recombinant Rabbit Monoclonal Antibody [JE35-30]

About this product

Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Phospholipid scramblase 1 (PLSCR1), a lipid-binding protein that enters the nucleus via the nonclassical NLS (257)GKISKHWTGI (266). The structure of the nuclear localisation sequence of scramblase PLSCR1 complexed to importin was determined using X-ray diffraction with a resolution of 2.20 Ångströms. It is found in most mammals including humans. The import sequence lacks a continuous stretch of positively charged residues, and it is enriched in hydrophobic residues. Thus, Scramblase can transport negatively charged phospholipids from the inside of the cell to the outside of the cell. The importin structure is composed of many alpha helices that integrate the protein into membranes. The role of importin is to move proteins such as scramblase into the nucleus.

Specifications

Catalog number

HA722327

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Ca (2+) dependent phospholipid scramblase 1 antibody Ca (2+)-dependent phospholipid scramblase 1 antibody Erythrocyte phospholipid scramblase antibody MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of antibody MmTRA1a antibody MmTRA1b antibody Nor1 antibody Phospholipid scramblase 1 antibody PL scramblase 1 antibody PLS1_HUMAN antibody PLSCR 1 antibody Plscr1 antibody Scramblase1 antibody Tra1 antibody Tra1a antibody Tra1b antibody Transplantability-associated protein 1 antibody Tras1 antibody Tras2 antibody

Abbreviation

PLSCR1

Swiss Prot

O15162 Human

Cellular Locus

Cell membrane, Nucleus, Membrane, Cytoplasm, perinuclear region.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Scramblase 1 aa 11-60 / 318.

Isotype

IgG

Clone

JE35-30

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IP

Positive Control

SK-MEL-28 cell lysate, HeLa cell lysate, THP-1 cell lysate, MDA-MB-231 cell lysate, SK-MEL-28, human breast cancer tissue, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:200 ;FC: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes