TNFRSF14/HVEM Recombinant Rabbit Monoclonal Antibody [PSH06-42] - BSA and Azide free (Detector)

About this product

Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

Specifications

Catalog number

HA722677

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

HVEML antibody ATAR antibody CD270 antibody CD40 like protein precursor antibody Herpes virus entry mediator A antibody Herpesvirus entry mediator A antibody Herpesvirus entry mediator antibody Herpesvirus entry mediator ligand antibody HveA antibody HVEM antibody HVEM L antibody LIGHT antibody LIGHTR antibody TNFRSF14 antibody TNFSF 14 antibody TNR14_HUMAN antibody TR2 antibody Tumor necrosis factor receptor like gene2 antibody Tumor necrosis factor receptor superfamily member 14 antibody Tumor necrosis factor receptor superfamily member 14 precursor antibody Tumor necrosis factor receptor-like 2 antibody

Abbreviation

Tumor necrosis factor receptor superfamily member 14 Herpes virus entry mediator A Tumor necrosis factor receptor-like 2 CD270 TNFRSF14 HVEA, HVEM UNQ329/PRO509

Swiss Prot

Q92956 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human TNFRSF14 aa 39-202.

Isotype

IgG

Clone

PSH06-42

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det)

Positive Control

Recombinant standard Human TNFRSF14 protein (HA210556).

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH06-41] to Human TNFRSF14 antibody (Capture) (HA722676) and recombinant standard Human TNFRSF14 protein (HA210556) as the standard. The reference range value is 10.3-2,500 pg/ml.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4).

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes