ZEB Recombinant Rabbit Monoclonal Antibody [PSH0-61]

About this product

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain. The structure of the homeodomain is shown on the right. Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas A recent study suggested its contributing role in lung cancer invasiveness and metastasis development. Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.

Specifications

Catalog number

HA721438

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AREB 6 antibody AREB6 antibody BZP antibody Delta crystallin enhancer binding factor 1 antibody DELTA EF1 antibody FECD6 antibody MGC133261 antibody Negative regulator of IL 2 antibody Negative regulator of IL2 antibody NIL 2 A antibody NIL 2 A zinc finger protein antibody NIL 2A antibody NIL-2-A zinc finger protein antibody NIL2A antibody Posterior polymorphous corneal dystrophy 3 antibody PPCD3 antibody Represses interleukin 2 expression antibody TCF 8 antibody TCF-8 antibody TCF8 antibody Transcription factor 8 (represses interleukin 2 expression) antibody Transcription factor 8 antibody ZEB 1 antibody ZEB antibody ZEB1 antibody ZEB1_HUMAN antibody ZFHEP antibody ZFHX 1A antibody ZFHX1A antibody Zinc finger E box binding homeobox 1 antibody Zinc finger E-box-binding homeobox 1 antibody Zinc finger homeodomain enhancer binding protein antibody FLJ42816 antibody HSPC082 antibody KIAA0569 antibody SIP 1 antibody SIP1 antibody Smad Interacting Protein 1 antibody Smad-interacting protein 1 antibody SMADIP 1 antibody SMADIP1 antibody ZEB 2 antibody Zeb2 antibody ZEB2_HUMAN antibody Zfhx1b antibody ZFHX1B protein antibody Zfx1b antibody Zinc finger E box binding protein 2 antibody Zinc finger E-box-binding homeobox 2 antibody Zinc finger homeobox 1b antibody zinc finger homeobox protein 1 antibody Zinc finger homeobox protein 1b antibody

Abbreviation

ZEB1, AREB6, TCF8, ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B

Swiss Prot

P37275 Human, O60315 Human, Q64318 Mouse, Q9R0G7 Mouse, Q62947 Rat,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human ZEB1 aa 1-400 / 1,124.

Isotype

IgG

Clone

PSH0-61

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Jurkat cell lysate, SK-OV-3 cell lysate, HeLa cell lysate, HEK-293 cell lysate, U87-MG cell lysate, MG-63 cell lysate, human colon tissue, human kidney tissue, human ovary carcinoma tissue, mouse heart tissue, mouse kidney tissue, mouse liver tissue, mouse lung tissue, mouse stomach tissue, mouse testis tissue, rat kidney tissue, rat liver tissue, rat lung tissue, rat small intestine tissue, rat testis tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:1,000 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 124 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes