Human CD63 Recombinant Rabbit Monoclonal Antibody [PSH08-44] - BSA and Azide free (Detector)

About this product

Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Specifications

Catalog number

HA722989

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Lysosomal associated membrane protein 3 antibody CD 63 antibody CD63 antibody CD63 antigen (melanoma 1 antigen) antibody CD63 antigen antibody CD63 antigen melanoma 1 antigen antibody CD63 molecule antibody CD63_HUMAN antibody gp55 antibody Granulophysin antibody LAMP 3 antibody LAMP-3 antibody LAMP3 antibody LIMP antibody Lysosomal-associated membrane protein 3 antibody Lysosome associated membrane glycoprotein 3 antibody Lysosome-associated membrane glycoprotein 3 antibody Mast cell antigen AD1 antibody ME491 antibody Melanoma 1 antigen antibody Melanoma associated antigen ME491 antibody Melanoma associated antigen MLA1 antibody Melanoma-associated antigen ME491 antibody MGC72893 antibody MLA 1 antibody MLA1 antibody NGA antibody Ocular melanoma associated antigen antibody Ocular melanoma-associated antigen antibody OMA81H antibody PTLGP40 antibody Tetraspanin 30 antibody Tetraspanin-30 antibody Tspan 30 antibody Tspan-30 antibody TSPAN30 antibody

Abbreviation

CD63 antigen Granulophysin Lysosomal-associated membrane protein 3 LAMP-3 Lysosome integral membrane protein 1 Limp1 Melanoma-associated antigen ME491 OMA81H CD63 MLA1, TSPAN30

Swiss Prot

P08962 Human

Cellular Locus

Cell membrane. Endosome. Lysosome. Membrane. Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human CD63 aa 103-203 (HA210764).

Isotype

IgG

Clone

PSH08-44

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det)

Positive Control

Recombinant Human CD63 Protein (HA210764).

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH08-43] to Human CD63 antibody (Capture) (HA722988) and recombinant Human CD63 protein (HA210764) as the standard. The reference range value is 15.6-2,000 pg/ml.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4).

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes