ADRM1 Recombinant Rabbit Monoclonal Antibody [PSH05-41]

About this product

Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. As the degradation machinery that is responsible for ~70% of intracellular proteolysis,[13] proteasome complex (26S proteasome) plays a critical roles in maintaining the homeostasis of cellular proteome. Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in parallel, some key regulatory proteins fulfill their biological functions via selective degradation; furthermore, proteins are digested into peptides for MHC class I antigen presentation. To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. Thus, 19S regulatory particle pertains a series of important capabilities to address these functional challenges. To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special degradative tag, the ubiquitinylation.

Specifications

Catalog number

HA722270

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

110 kDa cell membrane glycoprotein antibody adhesion regulating molecule 1 antibody Adhesion-regulating molecule 1 antibody ADRM 1 antibody Adrm1 antibody ADRM1_HUMAN antibody ARM 1 antibody ARM-1 antibody ARM1 antibody Gp110 antibody hRpn13 antibody M (r) 110,000 surface antigen antibody Proteasomal ubiquitin receptor ADRM1 antibody proteasome regulatory particle non ATPase 13 antibody Proteasome regulatory particle non-ATPase 13 antibody Regulatory particle non ATPase 13 antibody Rpn13 antibody Rpn13 homolog antibody

Abbreviation

ADRM1, GP110

Swiss Prot

Q16186 Human, Q9JKV1 Mouse, Q9JMB5 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Monkey

Immunogen

Recombinant protein within human ADRM1 aa 258-407 / 407.

Isotype

IgG

Clone

PSH05-41

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC, IP

Positive Control

HEK-293 cell lysate, HeLa cell lysate, SK-MEL-28 cell lysate, MCF7 cell lysate, Ramos cell lysate, Raji cell lysate, K-562 cell lysate, U-2 OS cell lysate, SW620 cell lysate, COS-1 cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, C6 cell lysate, SK-MEL-28, NIH/3T3, PC-12.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:500 ;FC: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes