Product details

AGER Polyclonal antibody

Catalog number AN006020L-01

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Price for AN006020L-01

Size / count 25 µL

Specifications

Catalog number: AN006020L-01
Size / count: 25 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: AGER (Advanced Glycosylation End-Product Specific Receptor) is a Protein Coding gene. Diseases associated with AGER include Diabetic Angiopathy and Hyperglycemia. Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans. Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B.
Abbreviation: AGER
UniProt: Q15109
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant Human AGER protein expressed by Mammalian
Target: MGC; SCARJ; AGER; RAGE; SCARJ1; Advanced glycosylation end product-specific receptor; advanced glycosylation end-product specific receptor; MGC2235; Receptor for Advanced Glycation End products; Receptor for advanced glycosylation end products
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Neuroscience; Cardiovascular
Purification: Antigen Affinity Purification
Concentration: 1 mg/mL
Dilution: WB 1:5000-1:10000; IHC 1:100-1:200
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
Calculated Molecular Weight: 42 kDa
Observed Molecular Weight: 43 kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for AGER Polyclonal antibody?

The catalog number for AGER Polyclonal antibody is AN006020L.

What sizes are available for AGER Polyclonal antibody?

AGER Polyclonal antibody is available in the following size(s): 25 µL, 100 µL.

How many pack sizes does AGER Polyclonal antibody come in?

AGER Polyclonal antibody is available in 2 different pack sizes.

Is AGER Polyclonal antibody in stock?

AGER Polyclonal antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AGER Polyclonal antibody?

AGER Polyclonal antibody is manufactured by Elabscience.

What is the estimated delivery time for AGER Polyclonal antibody?

Estimated delivery time for AGER Polyclonal antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for AGER Polyclonal antibody?

The safety data sheet for AGER Polyclonal antibody is available here: https://789.bio/eb/meWuPO.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.