CD32A + CD32B + CD32C Recombinant Rabbit Monoclonal Antibody [JE64-17]

About this product

CD32A: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. CD32B: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. CD32C: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Specifications

Catalog number

HA721930

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor II-b Low affinity immunoglobulin gamma Fc region receptor II-c IgG Fc receptor II-a IgG Fc receptor II-b IgG Fc receptor II-c CDw32 Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a) Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b) Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c) CD32 FCGR2A FCGR2B FCGR2C CD32, FCG2, FCGR2A1, IGFR2

Abbreviation

Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor II-b Low affinity immunoglobulin gamma Fc region receptor II-c IgG Fc receptor II-a IgG Fc receptor II-b IgG Fc receptor II-c CDw32 Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a) Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b) Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c) CD32 FCGR2A FCGR2B FCGR2C CD32, FCG2, FCGR2A1, IGFR2

Swiss Prot

P12318 Human, P31994 Human, P31995 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD32A aa 60-109 / 317.

Isotype

IgG

Clone

JE64-17

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

K-562 cell lysate, Raji cell lysate, HL-60 cell lysate, human lung tissue lysate, human pancreas tissue, human spleen tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:500-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes