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![Phospho-AKT1 (S129) Recombinant Rabbit Monoclonal Antibody [JE59-50] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea82423/imageurl/ha721677.webp)
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Product details
Catalog number HA721677
Price for HA721677
Size / count 100 µL
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβ or RacPK-βb) and Akt 3 (also designated PKBγ or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. Activation is dependent on PDGFR-β Tyr residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by Insulin or Insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity. The phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in Insulin/IGF-1-stimulated cells by an upstream kinase (s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin, suggesting that the protein signals downstream of the PI kinases.
The catalog number for Phospho-AKT1 (S129) Recombinant Rabbit Monoclonal Antibody [JE59-50] is HA721677.
Phospho-AKT1 (S129) Recombinant Rabbit Monoclonal Antibody [JE59-50] is available in the following size(s): 100 µL.
Phospho-AKT1 (S129) Recombinant Rabbit Monoclonal Antibody [JE59-50] is currently made to order / not held in immediate stock. Contact us for lead time.
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβ or RacPK-βb) and Akt 3 (also designated PKBγ or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are
Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.
A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.
Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.
