MAG Recombinant Rabbit Monoclonal Antibody [PSH02-41]

About this product

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).

Specifications

Catalog number

HA721818

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

GMA antibody MAG antibody MAG_HUMAN antibody Myelin associated glycoprotein antibody Myelin-associated glycoprotein antibody S MAG antibody S-MAG antibody Sialic acid binding Ig like lectin 4A antibody Sialic acid binding immunoglobulin like lectin 4A antibody Siglec 4a antibody Siglec-4a antibody SIGLEC4A antibody SPG75 antibody

Abbreviation

MAG, GMA

Swiss Prot

P20916 Human,P20917 Mouse,P07722 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human MAG aa 1- 536 / 626.

Isotype

IgG

Clone

PSH02-41

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue, IP, IHC-Fr

Positive Control

Mouse brain (no heat) tissue lysate, mouse cerebellum tissue lysate, rat brain (no heat) tissue lysate, rat cerebellum tissue lysate, human brain tissue, human cerebellum tissue, mouse brain tissue, mouse cerebellum tissue, mouse hippocampus tissue, rat brain tissue, rat cerebellum tissue, rat hippocampus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IHC-P: 1:2,000-1:5,000 ;IF-Tissue: 1:200 ;IP: 1-2μg/sample ;IHC-Fr: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 69 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes