SHC Recombinant Rabbit Monoclonal Antibody [JE57-45]

Catalog number HA722564

Price for HA722564

Size / count 100 µL

About this product

Overexpression of SHC proteins are associated with cancer mitogenesis, carcinogenesis and metastasis. The SHC and its adaptor proteins transmit signaling of the cell surface receptors such as EGFR, erbV-2 and insulin receptors. p52SHC and p46SHC activate the Ras-ERK pathway. p66SHC inhibits ERK1/2 activity and antagonize mitogenic and survival abilities of T-lymphoma Jurkat cell lines. A rise in p66SHC promotes stress induced apoptosis. p66SHC functionally is also involved in regulating oxidative and stress- induced apoptosis – mediating steroid action through the redox signaling pathway. P52SHC and p66SHC have been found in steroid hormone-regulated cancer and metastasizes.

Specifications

Catalog number: HA722564
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FLJ26504 antibody p66 antibody p66SHC antibody SH2 domain protein C1 antibody SHC (Src homology 2 domain containing) transforming protein 1 antibody SHC 1 antibody SHC A antibody SHC adaptor protein 1 antibody Shc antibody SHC transforming protein 1 antibody SHC transforming protein antibody SHC-transforming protein 1 antibody SHC-transforming protein 3 antibody SHC-transforming protein A antibody SHC1 antibody SHC1_HUMAN antibody SHCA antibody Src homology 2 domain-containing-transforming protein C1 antibody
Abbreviation: SHC1, SHC, SHCA
Swiss Prot: P29353 Human, P98083 Mouse, Q5M824 Rat
Cellular Locus: Cytoplasm, Cell junction, focal adhesion; Mitochondrion matrix; Mitochondrion.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within
Isotype: IgG
Clone: JE57-45
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: Jurkat cell lysate, HepG2 cell lysate, A431 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C6 cell lysate, human lung cancer tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 63 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SHC Recombinant Rabbit Monoclonal Antibody [JE57-45]?

The catalog number for SHC Recombinant Rabbit Monoclonal Antibody [JE57-45] is HA722564.

What sizes are available for SHC Recombinant Rabbit Monoclonal Antibody [JE57-45]?

SHC Recombinant Rabbit Monoclonal Antibody [JE57-45] is available in the following size(s): 100 µL.

Is SHC Recombinant Rabbit Monoclonal Antibody [JE57-45] in stock?

SHC Recombinant Rabbit Monoclonal Antibody [JE57-45] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SHC Recombinant Rabbit Monoclonal Antibody [JE57-45] used for?

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.