Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector)

Catalog number HA723096

Price for HA723096

Size / count 100 µL

About this product

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.

Specifications

Catalog number: HA723096
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CTL tryptase antibody CTLA3 antibody Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody Cytotoxic T lymphocyte associated serine esterase 3 antibody Cytotoxic T lymphocyte proteinase 1 antibody Cytotoxic T-lymphocyte proteinase 1 antibody Fragmentin 1 antibody Fragmentin-1 antibody GRAA_HUMAN antibody Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease) antibody Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody Granzyme A antibody Granzyme A precursor antibody Granzyme-1 antibody GZMA antibody H factor antibody Hanukah factor serine protease antibody Hanukkah factor antibody HF antibody HFSP antibody TSP1 antibody
Abbreviation: Granzyme A CTL tryptase Cytotoxic T-lymphocyte proteinase 1 Fragmentin-1 Granzyme-1 Hanukkah factor GZMA CTLA3, HFSP
Swiss Prot: P12544 Human
Cellular Locus: Secreted.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human Granzyme A aa 29-262.
Isotype: IgG
Clone: PSH09-37
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Det)
Positive Control: Recombinant Human Granzyme A protein (HA210916).
Concentration: 1 mg/mL
Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH09-36] to Human Granzyme A antibody (Capture) (HA723095) and Recombinant Human Granzyme A protein (HA210916) as the standard. The reference range value is 15.6-2,000 pg/ml.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector)?

The catalog number for Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector) is HA723096.

What sizes are available for Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector)?

Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector) is available in the following size(s): 100 µL.

Is Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector) in stock?

Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Human Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH09-37] - BSA and Azide free (Detector) used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.