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Product details

Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56]

Catalog number HA721645

Price for HA721645

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Size / count 100 µL

About this product

Legumain is a protein that in humans is encoded by the LGMN gene. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Specifications

Catalog number
HA721645
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9000-83-3
Product Name Alternative
AEP antibody Asparaginyl endopeptidase antibody cysteine 1 antibody Cysteine protease 1 antibody EC 3.4.22.34 antibody Legumain antibody LGMN antibody LGMN_HUMAN antibody LGMN1 antibody Protease antibody Protease cysteine 1 (legumain) antibody Protease cysteine 1 antibody PRSC1 antibody
Abbreviation
LGMN, PRSC1
Swiss Prot
Q99538 Human, O89017 Mouse, Q9R0J8 Rat
Cellular Locus
Lysosome.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human Legumain aa 151-350 / 433.
Isotype
IgG
Clone
JE35-56
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
HT-29 cell lysate, HeLa cell lysate, 293T cell lysate, Jurkat cell lysate, Neuro-2a cell lysate, MCF7 cell lysate, RAW264.7 cell lysate, mouse kidney tissue lysate, mouse placenta tissue lysate, rat kidney tissue lysate, human kidney tissue lysate, human kidney tissue, human placenta tissue, rat kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:200-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 49 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes

Frequently Asked Questions

What is the catalog number for Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56]?

The catalog number for Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56] is HA721645.

What sizes are available for Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56]?

Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56] is available in the following size(s): 100 µL.

Is Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56] in stock?

Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56] used for?

Legumain is a protein that in humans is encoded by the LGMN gene. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentat

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

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