AKR1C3 Recombinant Rabbit Monoclonal Antibody [JE36-28]

About this product

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin D2, prostaglandin H2, and phenanthrenequinone, and the oxidation of prostaglandin F2α to prostaglandin D2. It is also capable of metabolizing estrogen and progesterone. AKR1C3 may play an important role in the development of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. AKR1C3 is overexpressed in prostate cancer (PCa) and is associated with the development of castration-resistant prostate cancer (CRPC). In addition, AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.

Specifications

Catalog number

HA722198

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

17 beta HSD 5 antibody 17 beta hydroxysteroid dehydrogenase type 5 antibody 17-beta-HSD 5 antibody 17-beta-hydroxysteroid dehydrogenase type 5 antibody 2-dihydrobenzene-1 antibody 2-diol dehydrogenase antibody 20 alpha-hydroxysteroid dehydrogenase antibody 20-alpha-hydroxysteroid dehydrogenase antibody 3 alpha hydroxysteroid dehydrogenase type II antibody 3-alpha-HSD type 2 antibody 3-alpha-HSD type II antibody 3-alpha-HSD type II, brain antibody 3-alpha-hydroxysteroid dehydrogenase type 2 antibody AK1C3_HUMAN antibody AKR1 C3 antibody Akr1c18 antibody AKR1C3 antibody Aldo keto reductase family 1 member C3 antibody Aldo-keto reductase family 1 member C3 antibody brain antibody Chlordecone reductase antibody Chlordecone reductase homolog HAKRb antibody DD-3 antibody DD3 antibody DDH1 antibody DDX antibody Dihydrodiol dehydrogenase 3 antibody Dihydrodiol dehydrogenase type I antibody Dihydrodiol dehydrogenase X antibody HA1753 antibody HAKRB antibody HAKRe antibody hluPGFS antibody HSD17B5 antibody Indanol dehydrogenase antibody KIAA0119 antibody PGFS antibody Prostaglandin F synthase antibody Testosterone 17-beta-dehydrogenase 5 antibody Trans-1 antibody Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase antibody Type IIb 3 alpha hydroxysteroid dehydrogenase antibody

Abbreviation

AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS

Swiss Prot

P42330 Human,

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human AKR1C3 aa 181-280 / 323.

Isotype

IgG

Clone

JE36-28

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

A549 cell lysate, HepG2 cell lysate, K-562 cell lysate, human kidney tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes