TAOK1 Recombinant Rabbit Monoclonal Antibody [JE65-14]

About this product

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system.

Specifications

Catalog number

HA722473

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

2810468K05Rik antibody AU020252 antibody D130018F14Rik antibody EC 2.7.11.1 antibody FLJ14314 antibody hKFC B antibody hKFC-B antibody KIAA1361 antibody Kinase from chicken homolog B antibody MAP3K16 antibody MARK kinase antibody MARKK antibody MGC29021 antibody Microtubule affinity regulating kinase kinase antibody mKIAA1361 antibody Prostate-derived sterile 20-like kinase 2 antibody PSK2 antibody Serine/threonine kinase TAO1 antibody Serine/threonine protein kinase TAO1 antibody Serine/threonine protein kinase TAO1 homolog antibody Serine/threonine-protein kinase TAO1 antibody STE20 like kinase antibody STE20 like kinase PSK2 antibody STE20-like kinase PSK2 antibody TAO kinase 1 antibody Taok1 antibody TAOK1_HUMAN antibody Thousand and one amino acid protein 1 antibody

Abbreviation

Serine/threonine-protein kinase TAO1 Kinase from chicken homolog B (hKFC-B) MARK Kinase (MARKK) Prostate-derived sterile 20-like kinase 2 (PSK-2; PSK2; Prostate-derived STE20-like kinase 2) Thousand and one amino acid protein kinase 1 (TAOK1; hTAOK1) TAOK1 KIAA1361, MAP3K16, MARKK

Swiss Prot

Q7L7X3 Human, Q5F2E8 Mouse, O88664 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human TAOK1 aa 941-990 / 1,001.

Isotype

IgG

Clone

JE65-14

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

HeLa cell lysate, Jurkat cell lysate, HCT 116 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, PC-12, human liver tissue, human lung cancer tissue, mouse brain tissue, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:200-1:1,000 ;IF-Cell: 1:100 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 116 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes