GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23]

Catalog number HA722409

Price for HA722409

Size / count 100 µL

About this product

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene. GRAF1 is a multidomain protein that is necessary for the CLIC/GEEC endocytic pathway. By virtue of an N-terminal BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of dynamin action abrogates CLIC/GEEC endocytosis. There are several members of the GRAF family of proteins, including GRAF2, GRAF3, and oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (leukaemia and mental retardation, respectively). Recently, autoantibodies to ARHGAP26 have been implicated in autoimmune cerebellar ataxia.

Specifications

Catalog number: HA722409
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: arhgap26 antibody FLJ42530 antibody GRAF antibody GRAF1 antibody GTPase regulator associated with focal adhesion kinase antibody GTPase regulator associated with focal adhesion kinase pp125 (FAK) antibody KIAA0621 antibody oligophrenin 1 like protein antibody Oligophrenin-1-like protein antibody oligophrenin1like protein antibody OPHN1L antibody OPHN1L1 antibody RHG26_HUMAN antibody Rho GTPase activating protein 26 antibody Rho GTPase activating protein26 antibody Rho GTPase-activating protein 26 antibody Rho-type GTPase-activating protein 26 antibody
Abbreviation: ARHGAP26, GRAF, KIAA0621, OPHN1L
Swiss Prot: Q9UNA1 Human, Q6ZQ82 Mouse,
Cellular Locus: Cell junction, focal adhesion, Cytoplasm, cytoskeleton; Endosome membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human GRAF aa 750-814.
Isotype: IgG
Clone: JE62-23
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: Caco-2 cell lysate, Jurkat cell lysate, HepG2 cell lysate, MCF7 cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, human heart tissue, human brain tissue, mouse brain tissue, rat brain tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 92 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23]?

The catalog number for GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23] is HA722409.

What sizes are available for GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23]?

GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23] is available in the following size(s): 100 µL.

Is GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23] in stock?

GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23] is currently made to order / not held in immediate stock. Contact us for lead time.

What is GRAF Recombinant Rabbit Monoclonal Antibody [JE62-23] used for?

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.