SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20]

Catalog number HA721316

Price for HA721316

Size / count 100 µL

About this product

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B.

Specifications

Catalog number: HA721316
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Signal regulatory protein alpha type 1 antibody Bit antibody Brain Ig like molecule with tyrosine based activation motifs antibody Brain Ig-like molecule with tyrosine-based activation motifs antibody Brain immunoglobulin like molecule with tyrosine based activation motifs antibody CD172 antigen like family member A antibody CD172 antigen-like family member A antibody CD172a antibody CD172a antigen antibody Inhibitory receptor SHPS-1 antibody Macrophage fusion receptor antibody MFR antibody MYD 1 antibody Myd 1 antigen antibody MyD-1 antigen antibody p84 antibody Protein tyrosine phosphatase non receptor type substrate 1 antibody PTPNS1 antibody SHP substrate 1 antibody SHPS-1 antibody SHPS1 antibody SHPS1_HUMAN antibody Signal regulatory protein alpha 2 antibody Signal regulatory protein alpha 3 antibody Signal regulatory protein alpha antibody Signal regulatory protein alpha type 2 antibody Signal-regulatory protein alpha-1 antibody Signal-regulatory protein alpha-2 antibody Signal-regulatory protein alpha-3 antibody SIRP antibody Sirp-alpha-1 antibody Sirp-alpha-2 antibody Sirp-alpha-3 antibody SIRPA antibody SIRPalpha antibody SIRPalpha1 antibody SIRPalpha2 antibody SIRPalpha3 antibody Tyrosine phosphatase SHP substrate 1 antibody Tyrosine protein phosphatase non receptor type substrate 1 antibody Tyrosine-protein phosphatase non-receptor type substrate 1 antibody
Abbreviation: Tyrosine-protein phosphatase non-receptor type substrate 1 SHP substrate 1; SHPS-1 Brain Ig-like molecule with tyrosine-based activation motifs (Bit) CD172 antigen-like family member A Inhibitory receptor SHPS-1 Macrophage fusion receptor MyD-1 antigen Signal-regulatory protein alpha-1 (Sirp-alpha-1) Signal-regulatory protein alpha-2 (Sirp-alpha-2) Signal-regulatory protein alpha-3 (Sirp-alpha-3) p84 CD172a SIRPA BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Swiss Prot: P78324 Human, P97797 Mouse, P97710 Rat
Cellular Locus: Membrane
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human SIRP alpha aa 395-504 (Cytoplasmic).
Isotype: IgG
Clone: JE36-20
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: THP-1 cell lysate, HL-60 cell lysate, mouse brain tissue lysate, human lymph node tissue, human spleen tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:1,000 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 55 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20]?

The catalog number for SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20] is HA721316.

What sizes are available for SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20]?

SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20] is available in the following size(s): 100 µL.

Is SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20] in stock?

SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20] used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.