Bulk Anti-Human CD20 (2H7) Antibody

Catalog number ICH1012-25mg

Price for ICH1012-25mg

Size / count 25 mg

Specifications

Catalog number: ICH1012-25mg
Size / count: 25 mg
Dry ice: No
Hazardous: No
Discontinued: No
Background: The CD20 antigen, also called MS4A1, B1 and Bp35, is a non-glycosylated, transmembrane spanning, phosphoprotein. The CD20 protein is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells, and is synchronous with the expression of surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset. CD20 has been shown to be heavily phosphorylated in activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn), and exists in a complex with MHC class I and II, CD53, CD81, and CD82. Extensive CD20 cross-linking may also influence cell death by apoptosis. Therapy with antibodies against CD20 is a widely used regimen in the treatment of all B cell lymphomas and leukemias.
CAS Number: 9007-83-4
Specifications: Anti-CD20 In Vivo Antibody - Low Endotoxin (2H7) recognizes an epitope on Human CD20
Product Name Alternative: B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, MS4A1
UniProt: P11836
Host: Mouse
Species Reactivity: Human
Target: CD20
Isotype: IgG2b Kappa
Clone: 2H7
Applications: Flow Cytometry, CyTOF, IHC (Frozen), Immunoprecipitation
Purification Method: This monoclonal antibody was purified using Protein A
Concentration: 1.0 - 5.0 mg/mL
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
Purity: >95% by SDS-PAGE and HPLC
Buffer: ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions: Blue ice
Storage Conditions: Anti-CD20 In Vivo Antibody - Low Endotoxin (2H7) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Aggregation: Aggregation level ≤ 5%
Applications Notes: Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control: https://www.ichor.bio/product/Mouse-IgG2b-Isotype-Control-for-In-Vivo-Low-Endotoxin-MPC-11-ICH2250

Frequently Asked Questions

What is the catalog number for Bulk Anti-Human CD20 (2H7) Antibody?

The catalog number for Bulk Anti-Human CD20 (2H7) Antibody is ICH1012-25mg.

What sizes are available for Bulk Anti-Human CD20 (2H7) Antibody?

Bulk Anti-Human CD20 (2H7) Antibody is available in the following size(s): 25 mg.

Is Bulk Anti-Human CD20 (2H7) Antibody in stock?

Bulk Anti-Human CD20 (2H7) Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.