Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin

Catalog number ICH1085-25mg

Price for ICH1085-25mg

Size / count 25 mg

Specifications

Catalog number: ICH1085-25mg
Size / count: 25 mg
Dry ice: No
Hazardous: No
Discontinued: No
Background: CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
CAS Number: 9007-83-4
Specifications: Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152
Product Name Alternative: Ctla4, Cytotoxic T-lymphocyte protein 4, CD152
UniProt: P09793
Host: Armenian Hamster
Species Reactivity: Mouse
Target: CTLA-4
Isotype: IgG1 Kappa
Clone: UC10-4F10-11
Applications: Flow Cytometry, Western Blot, Functional Assays, Immunoprecipitation
Purification Method: This monoclonal antibody was purified using Protein A
Concentration: ≥ 2.0 mg/mL
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
Purity: >95% by SDS-PAGE and HPLC
Buffer: ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions: Blue ice
Storage Conditions: Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.
Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.4, without BSA or sodium azide added.
Antigen Distribution: The UC10-4F10-11 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.
Aggregation: Aggregation level ≤ 5%
Applications Notes: Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control: https://www.ichor.bio/product/Armenian-Hamster-IgG-Isotype-Control-for-In-Vivo-Low-Endotoxin-PIP-ICH2251

Frequently Asked Questions

What is the catalog number for Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin?

The catalog number for Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin is ICH1085-25mg.

What sizes are available for Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin?

Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin is available in the following size(s): 25 mg.

Is Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin in stock?

Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin is currently made to order / not held in immediate stock. Contact us for lead time.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.