Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin

Catalog number ICH1114-50mg

Price for ICH1114-50mg

Size / count 50 mg

Specifications

Catalog number: ICH1114-50mg
Size / count: 50 mg
Dry ice: No
Hazardous: No
Discontinued: No
Background: RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor), is a member of the tumor necrosis factor family cytokine. RANKL is essential for osteoclast formation, activation, and survival. RANKL through interaction with its receptor RANK can modulate matrix degradation and inflammation. RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy. Consequently, novel drugs specifically targeting RANK, RANKL, and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various ailments associated with bone loss, such as arthritis, periodontal disease, cancer metastases, and osteoporosis.
CAS Number: 9007-83-4
Specifications: Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) recognizes an epitope on Mouse RANKL
Product Name Alternative: Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254
UniProt: O35235
Host: Rat
Species Reactivity: Mouse
Target: RANKL
Isotype: IgG2a Kappa
Clone: IK22/5
Applications: Flow Cytometry, Immunoprecipitation, Western Blot, Blocking, Immunofluorescence, IHC (Frozen)
Purification Method: This monoclonal antibody was purified using Protein G
Concentration: 1.0 mg/mL
Endotoxin: <0.5 EU/mg as determined by the LAL method
Purity: >95% by SDS-PAGE and HPLC
Buffer: ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions: Blue ice
Storage Conditions: Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) is stable when stored at 2-8°C. Do not freeze.This antibody is
Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Aggregation: Aggregation level ≤ 5%
Applications Notes: Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control: https://www.ichor.bio/product/Rat-IgG2a-In-Vivo-Isotype-Control-Low-Endotoxin-1-1-ICH2244

Frequently Asked Questions

What is the catalog number for Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin?

The catalog number for Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin is ICH1114-50mg.

What sizes are available for Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin?

Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin is available in the following size(s): 50 mg.

Is Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin in stock?

Anti-Mouse RANKL (IK22/5) In Vivo Antibody - Low Endotoxin is currently made to order / not held in immediate stock. Contact us for lead time.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.