Alemtuzumab Biosimilar - Research Grade

Specifications

Catalog number

ICH4002-50mg

Size / count

50 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Alemtuzumab biosimilar is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) directed against the 21-28 kD cell surface glycoprotein, CD52, is an IgG1 kappa antibody with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody. The alemtuzumab biosimilar has an approximate molecular weight of 150 kD and is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium.

Specifications

Detects human CD52. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Alemtuzumab.

Product Name Alternative

Campath-1 antigen, Cambridge pathology 1 antigen, HE5

UniProt

P31358

Host

Humanized

Species Reactivity

Human

Target

CD52

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

1.0 - 5.0 mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE and HPLC

Buffer

ICH3001-100mL ICH3002-100mL ICH3003-100mL

Shipping Conditions

Blue ice

Storage Conditions

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.

Isotype Control

https://ichor.bio/product/bulk-human-igg1-isotype-control-ib1-ich2254/