Tislelizumab Biosimilar - Research Grade

Specifications

Catalog number

ICH5004-5mg

Size / count

5 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pembrolizumab biosimilar is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. It is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa.

Specifications

Detects human PD-1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Tislelizumab.

Product Name Alternative

Programmed cell death protein 1, Pdcd1, CD279

UniProt

Q15116

Host

Humanized

Species Reactivity

Human

Target

PD-1

Isotype

IgG4

Applications

Functional Assays

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

1.0 - 5.0 mg/mL

Endotoxin

<1 EU/mg Determined by LAL gel clotting assay

Purity

>95% by SDS-PAGE and HPLC

Buffer

ICH3002

Shipping Conditions

Blue ice

Storage Conditions

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.

Applications Notes

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Isotype Control

https://ichor.bio/product/bulk-human-igg4-isotype-control-ib4-ich2257/