Purified Anti-Mouse Ly6A/E Antibody[D7]

Specifications

Catalog number

E-AB-F1191A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ly-6A/E, also known as Sca-1, is an 18 kD member of the Ly-6 multigene family. Ly6A/E is a glycosylphosphatidylinositol (GPI) -linked protein expressed on hematopoietic stem cells. In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, DBA/2, SJL, SWR, and 129), Ly-6A/E is also expressed on peripheral B lymphocytes and thymic and peripheral T lymphocytes. Strains expressing the Ly-6.1 haplotype (e.g., BALB/c, CBA, C3H/He, DBA/1, and NZB) have low Ly-6A/E expression on resting peripheral lymphocytes. The expression of Ly-6A/E on lymphocytes is upregulated upon activation from both Ly6.1 and Ly6.2 haplotype mice. Ly-6A/E is thought to be involved in the regulation of both T and B cell responses.

Abbreviation

Ly6A/E

UniProt

P05533

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse Ly6A/E protein

Target

SCA; Ly-6A2/Ly-6E; Ly-6A.2/Ly-6E.1; SCA-1; TAP; Ly6; Ly6a

Clonality

Monoclonal

Clone

D7

Conjugation

Unconjugated

Applications

FCM

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Rat IgG2a, κ