MUSK Recombinant Rabbit Monoclonal Antibody [PSH02-28]

About this product

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

Specifications

Catalog number

HA721808

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CMS9 antibody FADS antibody MDK 4 antibody MDK4 antibody MGC126323 antibody MGC126324 antibody Muscle antibody Muscle associated receptor tyrosine kinase antibody Muscle skeletal receptor tyrosine kinase antibody Muscle skeletal receptor tyrosine protein kinase antibody Muscle specific kinase receptor antibody Muscle specific tyrosine kinase receptor antibody Muscle specific tyrosine protein kinase receptor antibody Muscle-specific kinase receptor antibody Muscle-specific tyrosine-protein kinase receptor antibody MuSK antibody MUSK_HUMAN antibody Neural fold somite kinase 1 antibody Neural fold somite kinase 2 antibody Neural fold somite kinase 3 antibody Neural fold somite kinase1 antibody Neural fold somite kinase2 antibody Neural fold somite kinase3 antibody Nsk 1 antibody Nsk 2 antibody Nsk 3 antibody Nsk1 antibody Nsk2 antibody Nsk3 antibody Receptor tyrosine kinase MuSK antibody Skeletal muscle receptor tyrosine kinase antibody skeletal receptor tyrosine-protein kinase antibody

Abbreviation

MUSK

Swiss Prot

O15146 Human, Q61006 Mouse, Q62838 Rat

Cellular Locus

Postsynaptic cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human MUSK aa 1-516 / 869.

Isotype

IgG

Clone

PSH02-28

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Human brain tissue lysate, mouse brain tissue lysate, mouse hippocampus tissue lysate, rat brain tissue lysate, rat hippocampus tissue lysate, mouse skeletal muscle tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 97 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes