PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80]

Catalog number HA722184

Price for HA722184

Size / count 100 µL

About this product

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the adaptive immune system reacts to antigens that are associated with immune system activation by exogenous or endogenous danger signals. In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) – further mediated by a lower regulation of the gene Bcl-2.

Specifications

Catalog number: HA722184
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: B7 H antibody B7 H1 antibody B7 homolog 1 antibody B7-H1 antibody B7H antibody B7H1 antibody CD 274 antibody CD-274 antibody CD274 antibody CD274 antigen antibody CD274 molecule antibody MGC142294 antibody MGC142296 antibody OTTHUMP00000021029 antibody PD L1 antibody PD-L1 antibody PD1L1_HUMAN antibody PDCD1 ligand 1 antibody PDCD1L1 antibody PDCD1LG1 antibody PDL 1 antibody PDL1 antibody Programmed cell death 1 ligand 1 antibody Programmed death ligand 1 antibody RGD1566211 antibody
Abbreviation: Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Swiss Prot: Q9EP73 Mouse
Cellular Locus: Cell membrane, Early endosome membrane, Recycling endosome membrane.
Host: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant protein within mouse PD-L1 aa 1-250 / 290.
Isotype: IgG
Clone: PSH04-80
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, mIHC
Positive Control: RAW264.7 treated with 10μg/mL LPS for 8 hours cell lysate, J774A.1 treated with 1μg/mL LPS for 24 hours cell lysate, mouse spleen tissue lysate, mouse thymus tissue, mouse lung tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:200 ;mIHC: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 33 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80]?

The catalog number for PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80] is HA722184.

What sizes are available for PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80]?

PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80] is available in the following size(s): 100 µL.

Is PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80] in stock?

PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80] is currently made to order / not held in immediate stock. Contact us for lead time.

What is PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH04-80] used for?

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.