Anti-Exportin-4 XPO4 Antibody

About this product

Boster Bio Anti-Exportin-4 XPO4 Antibody (Catalog# A08052) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

A08052

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Exportin-4; Exp4; XPO4; KIAA1721

Gene Name

XPO4

UniProt

Q9C0E2

Host

Rabbit

Reactivity

Human

Immunogen

A partial length recombinant Exportin-4 protein (amino acids 775-1,000)

Clonality

Polyclonal

Applications

WB

Purification

Protein A Chromatography

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

Western blot: 1-3 µg/ml

Form

Liquid

Function

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. .

Molecular Weight

130139 MW

Shipping Conditions

Available

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Exportin-4

Subcellular Location

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.

Protein Name

Exportin-4