Anti-ZFYVE19 Antibody

About this product

Boster Bio Anti-ZFYVE19 Antibody (Catalog # A11198) . Tested in WB, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

A11198

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.<br><br>Chinwalla V., Oncogene 22:1400-1410(2003).<br>Ota T., Nat. Genet. 36:40-45(2004).<br>The MGC Project Team, Genome Res. 14:2121-2127(2004).

Synonyms

Abscission/NoCut checkpoint regulator; ANCHR; MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19; ZFYVE19; ANCHR, MPFYVE

Gene Name

ZFYVE19

UniProt

Q96K21

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human ZFYVE19.

Clonality

Polyclonal

Tissue Specificity

Detected in brain, heart, skeletal muscle, kidney and liver. .

Applications

WB, IHC

Field of Research

Cell Biology

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. .

Molecular Weight

51546 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Abscission/NoCut checkpoint regulator

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cleavage furrow . Midbody . Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis (PubMed:24814515) . .