Anti-GRASP Gripap1 Antibody

About this product

Boster Bio Anti-GRASP Gripap1 Antibody (Catalog # A13005-1) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A13005-1

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid protein encoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipper region and a carboxyl-terminal PDZ-binding motif. GRASP is involved with intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASP forms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. It also interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highly expressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary. <br><br>Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y.and Nakanishi, S. 2002. Tamalin, J. Neurosci. 22: 280-1289. <br>Hall, B.S., Gabernet-Castello, C., Voak, A., Goulding, D., Natesan, S.K. and Field, M.C. 2006. J. Biol. Chem. 281: 27600-27612. <br>Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K. and Jingami, H. 2007. Crystal structures of autoinhibitory PDZ domain of Tamalin EMBO J.26: 2192-2205.

Synonyms

GRIP1-associated protein 1; GRASP-1; Gripap1; Grasp1

Gene Name

GRIPAP1

UniProt

Q9JHZ4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence around aa. 814-818 (Q-E-I-V-R) derived from Rat GRASP.

Clonality

Polyclonal

Tissue Specificity

Expressed in the central nervous system; especially in neurons. .

Applications

WB

Field of Research

G Protein Signaling, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Ras Family, Receptors / Channels, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Concentration

1 mg/ml

Form

Liquid

Molecular Weight

96074 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

GRIP1-associated protein 1

Subcellular Location

Early endosome .