Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 — image 1 of 2

Product details

Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302

Catalog number M00173-2

Price for M00173-2

Size / count 100 µL

About this product

Boster Bio Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 (Catalog # M00173-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Specifications

Catalog number: M00173-2
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27 ; p27Kip1 ; CDKN1B; KIP1
Gene Name: CDKN1B
UniProt: P46527
Host: Rabbit
Reactivity: Human
Cross Reactivity: This antibody reacts to human p27Kip1 (Cyclin-dependent kinase inhibitor 1B) . It may also react to mouse p27Kip1, as predicted by immunogen homology.
Immunogen: A peptide corresponding to the C-terminus of human p27Kip1.
Clonality: Monoclonal
Clone: Clone: RM302
Tissue Specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Applications: IHC, WB
Field of Research: Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling
Purification: Protein A affinity purified from an animal origin-free culture supernatant
Concentration: 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form: Liquid
Function: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995) . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A- CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Molecular Weight: 22073 MW
Shipping Conditions: Available
Storage Conditions: Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Fragment: Rabbit IgG
Other Gene Names: Cyclin-dependent kinase inhibitor 1B
Subcellular Location: Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity) .
Prediction Reactivity: Mouse

Frequently Asked Questions

What is the catalog number for Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302?

The catalog number for Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 is M00173-2.

What sizes are available for Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302?

Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 is available in the following size(s): 100 µL.

Is Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 in stock?

Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302?

The safety data sheet for Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 is available here: https://www.bosterbio.com/msds?sku=M00173-2.

What is Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 used for?

Boster Bio Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 (Catalog # M00173-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.