Anti-Histone H2AX H2AFX Rabbit Monoclonal Antibody, Clone#RM214

About this product

Boster Bio Anti-Histone H2AX H2AFX Rabbit Monoclonal Antibody, Clone#RM214 (Catalog # M00241-2) . Tested in WB, ICC. ELISA, Luminex applications. This antibody reacts with Vertebrates.

Specifications

Catalog number

M00241-2

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX

Gene Name

H2AFX

UniProt

P16104

Host

Rabbit

Reactivity

Vertebrates

Cross Reactivity

This antibody reacts to Histone H2AX protein, independent of post-translational modifications. No cross-reactivity with other histone proteins. .

Immunogen

A peptide corresponding to the C-terminus of human Histone H2AX

Clonality

Monoclonal

Clone

Clone: RM214

Applications

WB, ICC, ELISA, Luminex

Field of Research

2339, DNA/RNA, DNA Damage Response, Epigenetics and Nuclear Signaling, Histones

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

Molecular Weight

15145 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Histone H2AX

Subcellular Location

Nucleus. Chromosome.