Anti-GnRH-Receptor / LH-RH Receptor Monoclonal Antibody

About this product

Boster Bio Anti-GnRH-Receptor / LH-RH Receptor Monoclonal Antibody (Catalog # M01442) . Tested in Flow Cytometry, IF, WB, IHC applications. This antibody reacts with Human, Rat.

Specifications

Catalog number

M01442

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR) . Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH) . GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.

Synonyms

Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R; GNRHR; GRHR

Gene Name

GNRHR and LHCGR

UniProt

P30968 ; P22888

Host

Mouse

Reactivity

Human, Rat

Immunogen

A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.

Clonality

Monoclonal

Clone

Clone: Clone: F1G4

Tissue Specificity

Pituitary, ovary, testis, breast and prostate but not in liver and spleen.

Applications

Flow Cytometry, IF, WB, IHC

Field of Research

Endocrine System, Neuroscience

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH) . This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

Molecular Weight

37731 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Fragment

IgG1, kappa

Other Gene Names

Gonadotropin-releasing hormone receptor

Subcellular Location

Cytoplasmic

Prediction Reactivity

Pig, Rabbit