Anti-LC3B MAP1LC3B Rabbit Monoclonal Antibody, Clone#RM293

About this product

Boster Bio Anti-LC3B MAP1LC3B Rabbit Monoclonal Antibody, Clone#RM293 (Catalog # M01524-1) . Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

M01524-1

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta; MAP1LC3B; MAP1ALC3

Gene Name

MAP1LC3B

UniProt

Q9GZQ8

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human LC3B (Autophagy-related protein LC3 B) (Microtubule-associated proteins 1A/1B light chain 3B) . It may also react to mouse or rat LC3B, as predicted by immunogen homology.

Immunogen

A peptide corresponding to the N-terminus of human LC3B.

Clonality

Monoclonal

Clone

Clone: RM293

Tissue Specificity

Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.

Applications

IHC, ICC, WB

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Molecular Weight

14688 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Microtubule-associated proteins 1A/1B light chain 3B

Subcellular Location

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity) .