Anti-CD146 Rabbit Monoclonal Antibody, Clone#RM249

About this product

Boster Bio Anti-CD146 Rabbit Monoclonal Antibody, Clone#RM249 (Catalog # M01683-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

M01683-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD146; MCAM; MUC18

Gene Name

MCAM

UniProt

P43121

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human CD146 (Cell surface glycoprotein MUC18) . This antibody may also react to mouse or rat CD146, as predicted by immunogen homology

Immunogen

A synthetic peptide corresponding to the residues near C-terminus of human CD146

Clonality

Monoclonal

Clone

Clone: RM249

Tissue Specificity

Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Applications

IHC, WB

Field of Research

Cancer, Cell Adhesion, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton/ECM, Immunology, Invasion/Microenvironment, Signal Transduction, Stem Cells

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Molecular Weight

71607 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Cell surface glycoprotein MUC18

Subcellular Location

Membrane; Single-pass type I membrane protein.

Prediction Reactivity

Mouse, Rat