Anti-Desmin (DESM) Rabbit Monoclonal Antibody, Clone#RM234

About this product

Boster Bio Anti-Desmin (DESM) Rabbit Monoclonal Antibody, Clone#RM234 (Catalog # M01948-2) . Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M01948-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Desmin; DES

Gene Name

DES

UniProt

P17661

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

This antibody reacts to human and mouse Desmin. This antibody may also react to rat and Bovine Desmin, as predicted by immunogen homology.

Immunogen

A peptide corresponding to human Desmin

Clonality

Monoclonal

Clone

Clone: RM234

Applications

IHC, WB

Field of Research

Complement, Immunology, Innate Immunity

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400) . In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190) . May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity) .

Molecular Weight

53536 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Desmin

Subcellular Location

Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm. Cell membrane, sarcolemma. Nucleus. Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190) . Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (By similarity) .

Prediction Reactivity

Rat, Bovine