Anti-CD276 (B7-H3) Rabbit Monoclonal Antibody, Clone#RM335

About this product

Boster Bio Anti-CD276 (B7-H3) Rabbit Monoclonal Antibody, Clone#RM335 (Catalog # M02220-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

M02220-1

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

CD276 antigen;4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276; CD276; B7H3; PSEC0249, UNQ309/PRO352

Gene Name

CD276

UniProt

Q5ZPR3

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to the cytoplasmic domain of human CD276 (B7-H3) .

Immunogen

A peptide corresponding to the C-terminus of human CD276 (B7-H3) .

Clonality

Monoclonal

Clone

Clone: RM335

Tissue Specificity

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

Applications

IHC, WB

Field of Research

Adaptive Immunity, Cancer, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage, Tumor Biomarkers

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Molecular Weight

57235 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

CD276 antigen

Subcellular Location

Membrane; Single-pass type I membrane protein.