Anti-Human IgG1 IGHG1 Rabbit Monoclonal Antibody, Clone#RM117

About this product

Boster Bio Anti-Human IgG1 IGHG1 Rabbit Monoclonal Antibody, Clone#RM117 (Catalog # M04575-5) . Tested in ELISA, ICC, IHC, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M04575-5

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Immunoglobulin heavy constant gamma 1 ; Ig gamma-1 chain C region ; Ig gamma-1 chain C region EU ; Ig gamma-1 chain C region KOL ; Ig gamma-1 chain C region NIE ; IGHG1

Gene Name

IGHG1

UniProt

P01857

Host

Rabbit

Reactivity

Human

Cross Reactivity

Reacts to the heavy chain of human IgG1. RM117 does not cross-react to any other IgG subclasses (IgG2, IgG3, IgG4), and shows no cross-reactivity to IgM, IgA, IgD, IgE. RM117 does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG.

Immunogen

Peptide corresponding to the hinge region of Human IgG1

Clonality

Monoclonal

Clone

Clone: RM117

Applications

ELISA, ICC, IHC, Flow Cytometry

Field of Research

Immunoglobulins, Immunology

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) .

Molecular Weight

36106 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Immunoglobulin heavy constant gamma 1

Subcellular Location

Secreted. Cell membrane.