Anti-Human IgD IGHD Rabbit Monoclonal Antibody, Clone#RM123

About this product

Boster Bio Anti-Human IgD IGHD Rabbit Monoclonal Antibody, Clone#RM123 (Catalog # M05183-1) . Tested in ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M05183-1

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Immunoglobulin heavy constant delta ; Ig delta chain C region ; Ig delta chain C region NIG-65 ; Ig delta chain C region WAH ; IGHD

Gene Name

IGHD

UniProt

P01880

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human IgD. No cross-reactivity with human IgG, IgM, IgA, or IgE.

Immunogen

Human IgD

Clonality

Monoclonal

Clone

Clone: RM123

Applications

ELISA

Field of Research

Immunoglobulins, Immunology

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) . IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:10702483, PubMed:11282392) .

Molecular Weight

42353 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Immunoglobulin heavy constant delta

Subcellular Location

Isoform 1: Secreted.