Anti-Human IgM IGHM Rabbit Monoclonal Antibody, Clone#RM121

About this product

Boster Bio Anti-Human IgM IGHM Rabbit Monoclonal Antibody, Clone#RM121 (Catalog # M07469-3) . Tested in ELISA, ICC, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

M07469-3

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Immunoglobulin heavy constant mu ; Ig mu chain C region ; Ig mu chain C region BOT ; Ig mu chain C region GAL ; Ig mu chain C region OU ; IGHM

Gene Name

IGHM

UniProt

P01871

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to the heavy chain of human IgM. No cross-reactivity with human IgG, IgA, IgD, or IgE.

Immunogen

Human IgM

Clonality

Monoclonal

Clone

Clone: RM121

Applications

ELISA, ICC, IHC

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) . IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553) .

Molecular Weight

49440 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Immunoglobulin heavy constant mu

Subcellular Location

Isoform 1: Secreted. During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.