Human TNF alpha Recombinant Protein

Catalog number R00002-8

Price for R00002-8

Size / count 5 µg

About this product

Tumor necrosis factor alpha (TNFSF2, TNF alpha) is a member of the TNF Superfamily. TNF alpha, being an endogenous pyrogen, is able to induce fever, to induce apoptotic cell death, to induce sepsis (through IL-1 & IL-6 production), to induce cachexia, induce inflammation, and to inhibit tumorigenesis and viral replication. Human TNF alpha Recombinant Protein is purified TNF alpha (TNFSF2) produced in yeast.

Specifications

Catalog number: R00002-8
Size / count: 5 µg
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Tumor necrosis factor, membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form; TNF; TNFA; TNFSF2
Gene Name: TNF
UniProt: P01375
Source: Yeast
Sequence: [object Object]
Applications: Cell Culture
Field of Research: Atherosclerosis, Cancer, Cardiovascular, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Metabolism, Signal Transduction, TNF Superfamily, Vascular Inflammation
Purification: Ion-exchange chromatography.
Bioactivity: In testing.
Form: Lyophilized
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208) . Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918) .
Shipping Conditions: Available
Storage Conditions: Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Subcellular Location: Cell membrane.

Frequently Asked Questions

What is the catalog number for Human TNF alpha Recombinant Protein?

The catalog number for Human TNF alpha Recombinant Protein is R00002-8.

What sizes are available for Human TNF alpha Recombinant Protein?

Human TNF alpha Recombinant Protein is available in the following size(s): 5 µg.

Is Human TNF alpha Recombinant Protein in stock?

Human TNF alpha Recombinant Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Human TNF alpha Recombinant Protein?

The safety data sheet for Human TNF alpha Recombinant Protein is available here: https://www.bosterbio.com/msds?sku=R00002-8.

What is Human TNF alpha Recombinant Protein used for?

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.