Mouse CXCL12 Recombinant Protein

About this product

The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 and its receptor CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis. Mouse CXCL12 Recombinant Protein is purified CXCL12 produced in yeast.

Specifications

Catalog number

R00053

Size / count

5 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Stromal cell-derived factor 1; SDF-1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; TPAR1; C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor; PBSF; Thymic lymphoma cell-stimulating factor; TLSF; Cxcl12; Sdf1

Gene Name

CXCL12

UniProt

P40224

Tissue Specificity

Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and muscle but not in lung, colon, brain, skin and stomach.

Source

Yeast

Sequence

[object Object]

Applications

Cell Culture

Field of Research

Chemokines, Host-Virus Interaction, Immunology, Innate Immunity, Interspecies Interaction, Microbiology

Purification

Ion-exchange chromatography.

Bioactivity

In testing.

Form

Lyophilized

Function

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity) . Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Subcellular Location

Secreted.