TrkA Rabbit Polyclonal Antibody

About this product

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on Tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.

Specifications

Catalog number

ER1706-86

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

gp140trk antibody High affinity nerve growth factor receptor antibody High affinity nerve growth factor receptor precursor antibody MTC antibody Neurotrophic tyrosine kinase receptor type 1 antibody NTRK1 antibody NTRK1_HUMAN antibody Oncogene TRK antibody p14-TrkA antibody p140 TrkA antibody p140-TrkA antibody Slow nerve growth antibody Trk A antibody TRK antibody Trk-A antibody TRK1 antibody TRK1-transforming tyrosine kinase protein antibody Tropomyosin-related kinase A antibody Tyrosine kinase receptor A antibody Tyrosine kinase receptor antibody

Abbreviation

Trk-A, NTRK1, MTC, TRK, TRKA

Swiss Prot

P04629 Human, Q3UFB7 Mouse, P35739 Rat

Cellular Locus

Cell membrane, Endosome, Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human TrkA aa 520-796 / 796.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

SHSY5Y cell lysate, SHG-44 cell lysate, PC-12, Human liver cancer tissue, human stomach cancer tissue, mouse brain tissue, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:100;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 87 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No