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![Dopamine Receptor D3 Recombinant Rabbit Monoclonal Antibody [JE33-33] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea81072/imageurl/ha721391.webp)
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Product details
Catalog number HA721391
Price for HA721391
Size / count 100 µL
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions.[citation needed] It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). Alpha-synuclein (α-Syn) aggregation via Lewy bodies inclusion, a pathogenic signature exclusively present in PD patients, is decreased by D3 agonists while DA content is elevated by inhibiting DA reuptake and breakdown. The regulation of α-Syn aggregation and clearance enhances brain-derived neurotrophic factor (BDNF) secretion, which ultimately ameliorates neuroinflammation and oxidative stress while promoting neurogenesis and interacting with other DA receptors. D3 agonists like 7-OH-DPAT, pramipexole, and rotigotine, among others, display antidepressant effects in rodent models of depression. Apomorphine has the ability to help PD patients with their cognition awareness. In addition to having antidepressant properties such as regulating the depression-like behaviors and depression development, pramipexole has the capability to prevent and slow down cell apoptosis as well as to restore damaged neural networks and connections while rotigotine help PD patients to attenuates hyperpyrexia syndrome and schizophrenia.
The catalog number for Dopamine Receptor D3 Recombinant Rabbit Monoclonal Antibody [JE33-33] is HA721391.
Dopamine Receptor D3 Recombinant Rabbit Monoclonal Antibody [JE33-33] is available in the following size(s): 100 µL.
Dopamine Receptor D3 Recombinant Rabbit Monoclonal Antibody [JE33-33] is currently made to order / not held in immediate stock. Contact us for lead time.
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that
Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.
