CRMP2 Recombinant Rabbit Monoclonal Antibody [JE31-53]

About this product

Members of the CRMP family were discovered independently in different species by several groups working in parallel. Among the five members of the family, CRMP-2 was first identified in 1995. Group of researchers led by Goshima found out that CRMP-2 played a role in the transduction of the extracellular Semaphorin 3A (Sema3A), an inhibitory protein for axonal guidance in chick dorsal root ganglion (DRG). The protein was first named as CRMP-62 having a relative molecular mass of 62 kDa and later referred as CRMP-2. Concurrently, a 64 kDa protein named as TOAD-64 for Turned On After Division, was shown to increase significantly during the development of the cortex of the brain. The cDNA sequence of TOAD-64 corresponded to that of rat CRMP-2. In 1996, mouse CRMP-4, often referred to as Ulip for Unc-33 like phosphoprotein, was discovered by Byk and colleagues, using a rabbit polyclonal antiserum which recognized a 64 kDa mouse brain specific phosphoprotein. In the same year, several other studies cloned CRMPs-1-4 in rat and dihydropyrimidinase (DHPase) homologous sequence of CRMPs-1, -2, and -4 in human fetal brain. Finally, in 2000, CRMP-5 was discovered using two-hybrid screenings of brain libraries or purification from a proteic complex. In following researches, CRMPs were studied as target antigens for autoantibodies in various autoimmune neurodegenerative disorders.

Specifications

Catalog number

HA721560

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Collapsin response mediator protein 2 antibody Collapsin response mediator protein antibody Collapsin response mediator protein hCRMP 2 antibody CRAM antibody CRMP 2 antibody CRMP-2 antibody CRMP2 antibody DHPRP 2 antibody DHPRP2 antibody Dihydropyrimidinase 2 antibody Dihydropyrimidinase like 2 antibody Dihydropyrimidinase like 2 long form antibody Dihydropyrimidinase related protein 2 antibody Dihydropyrimidinase-related protein 2 antibody DPYL 2 antibody DPYL2 antibody DPYL2_HUMAN antibody DPYSL 2 antibody Dpysl2 antibody DRP-2 antibody DRP2 antibody Musunc 33 antibody Musunc33 antibody N2A3 antibody TOAD 64 antibody TOAD64 antibody ULIP 2 protein antibody ULIP-2 antibody Ulip2 antibody Unc-33-like phosphoprotein 2 antibody

Abbreviation

Dihydropyrimidinase-related protein 2 DRP-2 Collapsin response mediator protein 2 (CRMP-2) N2A3 Unc-33-like phosphoprotein 2 (ULIP-2) DPYSL2 CRMP2, ULIP2

Swiss Prot

Q16555 Human, O08553 Mouse, P47942 Rat

Cellular Locus

Cytoplasm. Cytoskeleton.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human CRMP2 aa 473-572 / 572.

Isotype

IgG

Clone

JE31-53

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

U-87 MG cell lysate, SH-SY5Y cell lysate, Neuro-2a cell lysate, PC-12 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 62 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes