ADAM17-Specific antibody

Catalog number FNab00139

Discontinued

Price for FNab00139

Size / count 100 µg

This variant is discontinued and cannot be added to your cart.

Specifications

Catalog number: FNab00139
Size / count: 100 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
CAS Number: 9007-83-4
Synonyms: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)|Snake venom-like protease|TNF-alpha convertase|TNF-alpha-converting enzyme|ADAM17|CSVP|TACE
Gene ID: 6868
UniProt: P78536
Host: Rabbit
Reactivity: Human
Immunogen: ADAM metallopeptidase domain 17
Target: ADAM17
Clonality: Polyclonal
Isotype: IgG
Applications: ELISA, WB
Field of Research: Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience
Purification: Immunogen affinity purified
Dilution: WB: 1:200-1:2000; IHC: 1:20-1:200
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular Weight: 29 kDa
Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Frequently Asked Questions

What is the catalog number for ADAM17-Specific antibody?

The catalog number for ADAM17-Specific antibody is FNab00139.

Is ADAM17-Specific antibody in stock?

ADAM17-Specific antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

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