Phospho-MAPK14 (T180/Y182) antibody

Specifications

Catalog number

FNab10117

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Synonyms

Mitogen-activated protein kinase 14 (MAP kinase 14, MAPK 14) |Cytokine suppressive anti-inflammatory drug-binding protein (CSAID-binding protein, CSBP) |MAP kinase MXI2|MAX-interacting protein 2|Mitogen-activated protein kinase p38 alpha (MAP kinase p38 alpha) |Stress-activated protein kinase 2a (SAPK2a) |MAPK14|CSBP|CSBP1|CSBP2|CSPB1|MXI2|SAPK2A

Gene ID

1432

UniProt

Q16539

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK

Target

Phospho-MAPK14 (T180/Y182)

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Field of Research

Cancer, Immunology, Signal Transduction, epigenetics

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

41 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB