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![Patched / PTCH1 Recombinant Rabbit Monoclonal Antibody [PSH03-53] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81c2c/imageurl/ha722012.webp)
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Product details
Catalog number HA722012
Price for HA722012
Size / count 100 µL
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
The catalog number for Patched / PTCH1 Recombinant Rabbit Monoclonal Antibody [PSH03-53] is HA722012.
Patched / PTCH1 Recombinant Rabbit Monoclonal Antibody [PSH03-53] is available in the following size(s): 100 µL.
Patched / PTCH1 Recombinant Rabbit Monoclonal Antibody [PSH03-53] is currently made to order / not held in immediate stock. Contact us for lead time.
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedg
The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.
Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.
Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.
