LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43]

Catalog number HA721345

Price for HA721345

Size / count 100 µL

About this product

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. Fibrinogen-like protein1 FGL1, a liver-secreted protein, is another (major) LAG3 functional ligand independent of MHC-II. LAG3 also helps maintain CD8+ T cells in a tolerogenic state and, working with PD-1, helps maintain CD8 exhaustion during chronic viral infection. LAG3 is known to be involved in the maturation and activation of dendritic cells.

Specifications

Catalog number: HA721345
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CD223 antibody CD223 antigen antibody FDC protein antibody LAG-3 antibody Lag3 antibody LAG3_HUMAN antibody Lymphocyte activating 3 antibody Lymphocyte activation gene 3 antibody Lymphocyte activation gene 3 protein antibody Protein FDC antibody
Abbreviation: LAG3, FDC
Swiss Prot: P18627 Human, Q61790 Mouse
Cellular Locus: Cell membrane; Secreted.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within Human LAG-3 aa 1-500 / 525.
Isotype: IgG
Clone: PSH0-43
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: NIH/3T3 transfected with LAG3 cell lysate, human tonsil tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 57.4 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43]?

The catalog number for LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43] is HA721345.

What sizes are available for LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43]?

LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43] is available in the following size(s): 100 µL.

Is LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43] in stock?

LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43] is currently made to order / not held in immediate stock. Contact us for lead time.

What is LAG-3 Recombinant Rabbit Monoclonal Antibody [PSH0-43] used for?

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.