uPA Receptor Recombinant Mouse Monoclonal Antibody [A6E8-R]

About this product

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

Specifications

Catalog number

HA601296

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CD 87 antibody CD87 antibody CD87 antigen antibody MO 3 antibody MO3 antibody Monocyte activation antigen Mo3 antibody Plasminogen activator receptor urokinase antibody Plasminogen activator urokinase receptor antibody PLAUR antibody U PAR antibody u plasminogen activator receptor antibody U-PAR antibody u-plasminogen activator receptor form 2 antibody UPA receptor antibody uPAR antibody UPAR_HUMAN antibody Urinary plasminogen activator receptor antibody URKR antibody Urokinase plasminogen activator receptor antibody Urokinase plasminogen activator surface receptor antibody urokinase-type plasminogen activator (uPA) receptor antibody

Abbreviation

PLAUR

Swiss Prot

Q03405 Human

Cellular Locus

Cell membrane, invadopodium membrane; Secreted.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human uPA Receptor aa 51-250/335.

Isotype

IgG1

Clone

A6E8-R

Conjugation

Non-conjugated

Type

Recombinant Mouse monoclonal Antibody

Applications

WB

Positive Control

U937 treated with 200 nM PMA for 72 hours cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes