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![Mouse IL-10 Recombinant Rabbit Monoclonal Antibody [PS01-85] - BSA and Azide free (Capture) — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea81158/imageurl/ha721517.webp)
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Product details
Catalog number HA721517
Price for HA721517
Size / count 100 µL
IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit tumor metastasis. Additional investigation by multiple laboratories has generated data that further supports IL-10's immunostimulatory capacity in an immunoncology context. Expression of IL-10 from transfected tumor cell lines in IL-10 transgenic mice[30] or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity. More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells have at the site of an allergic reaction.
The catalog number for Mouse IL-10 Recombinant Rabbit Monoclonal Antibody [PS01-85] - BSA and Azide free (Capture) is HA721517.
Mouse IL-10 Recombinant Rabbit Monoclonal Antibody [PS01-85] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.
Mouse IL-10 Recombinant Rabbit Monoclonal Antibody [PS01-85] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.
IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can bloc
Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.
A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.
Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.
