FHIT Recombinant Rabbit Monoclonal Antibody [JE33-58]

About this product

Bis (5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. FHIT is also known as human accelerated region 10. It may, therefore, have played a key role in differentiating humans from apes. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis (5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. FHIT also acts as a tumor suppressor of HER2/neu driven breast cancer.

Specifications

Catalog number

HA722390

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AP3A hydrolase antibody AP3A hydrolase fragile site 3p14.2 antibody AP3Aase antibody Bis 5' adenosyl triphosphatase antibody Bis (5' adenosyl) triphosphatase antibody Diadenosine 5' 5''' P1 P3 triphosphate hydrolase antibody Dinucleosidetriphosphatase antibody FRA 3B antibody FRA3B antibody Fragile histidine triad antibody Fragile histidine triad gene antibody Fragile histidine triad protein antibody Tumor suppressor protein antibody FHIT

Abbreviation

FHIT

Swiss Prot

P49789 Human, O89106 Mouse, Q9JIX3 Rat

Cellular Locus

Cytoplasm, Mitochondrion, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human FHIT aa 1-147.

Isotype

IgG

Clone

JE33-58

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC, IF-Tissue

Positive Control

Jurkat cell lysate, HeLa cell lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, rat kidney tissue lysate, HeLa, human kidney tissue, mouse kidney tissue, rat kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:1,000 ;FC: 1:1,000 ;IF-Tissue: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 17 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes