LMNA Polyclonal Antibody

Specifications

Catalog number

D-AB-10192L-01

Size / count

25 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants.

Abbreviation

LMNA

UniProt

P02545

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant Human LMNA protein expressed by E.coli

Target

70 kDa lamin; Cardiomyopathy dilated 1A (autosomal dominant) ; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; Lamin A; Lamin A/C; Lamin A/C like 1; Lamin; Lamin C; Lamin-A/C; LDP1; LFP; LGMD1B; Limb girdle muscular dystrophy 1B (autosomal dominant) ; LMN 1; LMN A; LMN C; LMN1; LMNA; LMNA; LMNC; LMNL1; Prelamin A/C; PRO1; Renal carcinoma antigen NY REN 32; Renal carcinoma antigen NY-REN-32; Renal carcinoma antigen NYREN32

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB

Field of Research

Cancer; Signal Transduction; Tags and Cell Markers

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

63,64,65,69,71,74 kDa

Observed Molecular Weight

71,74 kDa

Isotype

IgG